DUBAI, United Arab Emirates — Iran’s supreme leader said Friday that negotiations with America “are not intelligent, wise or honorable” after President Donald Trump floated nuclear talks with Tehran.

Ayatollah Ali Khamenei also suggested that “there should be no negotiations with such a government,” but stopped short of issuing a direct order not to engage with Washington.

Khamenei’s remarks upend months of signals from Tehran to the United States that it wanted to negotiate over its rapidly advancing nuclear program in exchange for the lifting of crushing economic sanctions worth billions of dollars. Following Khamenei’s comments, the Iranian rial sunk to a record low of 872,000 rials to $1 in aftermarket trading.

What happens next remains unclear, particularly as reformist President Masoud Pezeshkian promised as recently as Thursday to enter into a dialogue with the West.

Khamenei’s remarks to air force officers in Tehran appeared to contradict his own earlier remarks in August that opened the door to talks. However, the 85-year-old Khamenei has always been careful with remarks about negotiating with the West. That includes balancing the demands of reformists within the country who want the talks against hard-line elements within Iran’s theocracy, including the paramilitary Revolutionary Guard.

Khamenei noted that Trump unilaterally withdrew from the earlier nuclear deal under which Iran drastically limited its enrichment of uranium and overall stockpile of the material, in exchange for crushing sanctions being removed.

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